Posaconazole Impurity 44 CAS 132962-42-6
| CAS No. | 132962-42-6 |
| Molecular Formula | C16H19N3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Posaconazole Impurity 44 (CAS 132962-42-6, C16H19N3SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution, Posaconazole Impurity 44 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 321.87 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Posaconazole Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19N3S HCl |
| Molecular Weight | 321.87 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Posaconazole Standards
- Posaconazole Impurity 25 (CAS 1042398-26-4)
- Posaconazole Impurity 112 (CAS 110931-77-6)
- Posaconazole Impurity 111 (CAS 112559-81-6)
- Posaconazole-d4 (CAS 1133712-26-1)
- Posaconazole Impurity 84 (CAS 122151-32-0)
- Posaconazole Impurity 115 (CAS 122151-38-6)
- Posaconazole Impurity 67(R,S,R,R) (CAS 1229428-89-0)
- Posaconazole Impurity 22(R,S,S,R) (CAS 1229428-90-3)
Recommended Standards
- Nimodipine Impurity N15 (CAS 101072-61-1)
- Afoxolaner Impurity 27 (CAS 2382920-55-8)
- Regorafenib Impurity 78 (CAS CATO-C4X-104778)
- 4-Bromo-3-nitro-1H-pyrrolo[3,2-c]pyridine (CAS 1190317-58-8)
- 4,5-Dihydro-1H-pyrido[2,3-b][1,4]diazepin-2(3H)-one (CAS 757966-64-6)
- Benzyl ((S)-1-(((S)-5-guanidino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate hydrochloride (CAS 70382-26-2)
- N-(3-Isopropoxybenzyl)-1-hexadecanamine (CAS 1040688-12-7)
- 2-[2-(dimethylamino)ethoxy]pyridin-4-amine (CAS 908117-05-5)
- 8-(Methylsulfonyl)-8-azabicyclo[3.2.1]oct-2-ene (CAS 1796948-10-1)
- Calcineurin Autoinhibitory Peptide (CAS 148067-21-4)
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