Telmisartan Impurity 3 CAS 133085-87-7
| CAS No. | 133085-87-7 |
| Molecular Formula | C16H15BrO2 |
| Molecular Weight | 319.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Telmisartan Impurity 3 (CAS 133085-87-7, C16H15BrO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Telmisartan Impurity 3 (C16H15BrO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 319.19 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Telmisartan Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15BrO2 |
| Molecular Weight | 319.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Br-containing |
Related Telmisartan Standards
- Telmisartan Impurity N2 (CAS 34981-09-4)
- Telmisartan Impurity 42 (CAS 1860008-29-2)
- Telmisartan Impurity 43 (CAS 884330-18-1)
- Telmisartan Impurity N20 (CAS 1083158-65-9)
- Telmisartan Impurity 94 (CAS CATO-C4X-135994)
- Telmisartan Impurity 63 (CAS CATO-C4X-135963)
- Telmisartan Impurity 87 (CAS CATO-C4X-135987)
- Telmisartan Impurity 12 (CAS 114772-38-2)
Recommended Standards
- 2-chloro-N-(4-chlorophenyl)-1-methyl-1H-indole-3-carboxamide 478049-45-5 KS-000039VU (CAS 478049-45-5)
- Loperamide impurity 13 (CAS 37742-98-6)
- Salmeterol Impurity (CAS 56443-33-5)
- 3-(4-Bromophenyl)-6-(piperazin-1-yl)pyridazine (CAS 1017168-56-7)
- Lifitegrast Impurity 111 (CAS CATO-C4X-2409111)
- Clemastine Impurity 32 (CAS CATO-C4X-183732)
- Trimetazidine Impurity 30 (CAS CATO-C4X-180330)
- N-((7-Methylimidazo[1,2-a]pyridin-2-yl)methyl)benzenesulfonamide (CAS 868972-31-0)
- Propofol Impurity 40 (CAS 258516-82-4)
- Methyl 6-oxohexahydropyridazine-4-carboxylate (CAS 153895-80-8)
- Discontinued: see P-714S-CN; (was Potassium dimethyl dithiocarbamate) (CAS 128-03-0)
- Erlotinib Impurity 102 (CAS CATO-C4X-1069102)
- (S)-6-fluoro-2,2-dimethylchroman-4-ol (CAS 235422-97-6)
- Des-Ala21-Tirzepatide (CAS CATO-CPTD788952)
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