Loperamide impurity 13 CAS 37742-98-6
| CAS No. | 37742-98-6 |
| Molecular Formula | C16H15BrO2 |
| Molecular Weight | 319.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Loperamide impurity 13.
CATO supplies Loperamide impurity 13 (CAS 37742-98-6), a pharmacopoeial impurity reference standard (molecular formula C16H15BrO2, MW 319.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Loperamide impurity 13 (C16H15BrO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 319.19 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H15BrO2 |
| Molecular Weight | 319.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Br-containing |
Related Loperamide Standards
- Loperamide impurity 14 (CAS 113817-55-3)
- Loperamide EP Impurity C (CAS 39512-49-7)
- Loperamide EP Impurity D (CAS 37743-41-2)
- Loperamide Impurity 16 (CAS CATO-C4X-178816)
- Loperamide EP Impurity H (CAS 61299-42-1)
- Loperamide (CAS 53179-11-6)
- Loperamide impurity 12 (CAS CATO-C4X-178812)
- Loperamide EP Impurity G (CAS 109572-89-6)
Recommended Standards
- Telmisartan Impurity 3 (CAS 133085-87-7)
- 3-(4-Bromophenyl)-6-(piperazin-1-yl)pyridazine (CAS 1017168-56-7)
- 2-chloro-N-(4-chlorophenyl)-1-methyl-1H-indole-3-carboxamide 478049-45-5 KS-000039VU (CAS 478049-45-5)
- n-(4-{[(4-bromophenyl)methyl]amino}phenyl)acetamide (CAS 1019555-56-6)
- Difluprednate Impurity 1 (CAS CATO-C4X-21781)
- Biotin EP Impurity D(Mixture of Diastereomers) (CAS 415725-35-8)
- Bumetanide Impurity 84 (CAS CATO-C4X-198684)
- Ethyl 5-chloro-1-(phenylsulfonyl)-1H-indole-2-carboxylate (CAS 158561-88-7)
- Methyl 2-(2,4-dimethylthiazol-5-yl)acetate (CAS 942034-79-9)
- 2-(Bromomethyl)pyrazine Hydrobromide (CAS 1421789-94-7)
- 4-Iodobutan-1-amine (CAS 408321-59-5)
- 6-Hydroxy-nicotinic acid tert-butyl ester (CAS 1342385-03-8)
- 5-(4-Chlorobenzyl)-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 31405-23-9)
- Acetyl tetrapeptide-9(Dermican LS 9837) (CAS 928006-50-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com