4-(4-Fluorophenyl)-6-methylpyrimidin-2-amine CAS 133256-49-2

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-Fluorophenyl)-6-methylpyrimidin-2-amine.

4-(4-Fluorophenyl)-6-methylpyrimidin-2-amine (CAS 133256-49-2), molecular formula C11H10FN3 and molecular weight 203.22 g/mol, is a CATO reference standard with documented purity and traceability.

4-(4-Fluorophenyl)-6-methylpyrimidin-2-amine (C11H10FN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4-(4-Fluorophenyl)-6-methylpyrimidin-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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