Pioglitazone impurity 40 CAS 1333112-55-2
| CAS No. | 1333112-55-2 |
| Molecular Formula | C18H22N2O2 |
| Molecular Weight | 298.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Pioglitazone impurity 40 (CAS 1333112-55-2) is a certified pharmaceutical impurity reference standard with the molecular formula C18H22N2O2 and a molecular weight of 298.38 g/mol.
Pioglitazone impurity 40 (C18H22N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pioglitazone impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22N2O2 |
| Molecular Weight | 298.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 2 |
Related Pioglitazone Standards
- Pioglitazone impurity 32 (CAS CATO-C4X-138332)
- Pioglitazone impurity 33 (CAS CATO-C4X-138333)
- Pioglitazone impurity 35 (CAS CATO-C4X-138335)
- Pioglitazone Aldehyde HCl (CAS 856255-80-6)
- Pioglitazone Bromo Impurity (CAS 669716-58-9)
- Pioglitazone impurity 34 (CAS CATO-C4X-138334)
- Pioglitazone impurity 43 (CAS CATO-C4X-138343)
- Pioglitazone impurity 46 (CAS CATO-C4X-138346)
Recommended Standards
- Budesonide Impurity 70 (CAS CATO-C4X-138970)
- Fudosteine impurity 75 (CAS CATO-C4X-144775)
- 4322AF 954572-84-0 C18H22N2O2 N-(5-Amino-2-methylphenyl)-2-(2,5-dimethylphenoxy) propanamide (CAS 954572-84-0)
- Fudosteine Impurity 81 (CAS CATO-C4X-144781)
- Cariprazine Impurity 38 (CAS CATO-C4X-240838)
- Ribavirin Impurity 42 (CAS 799-87-1)
- Benazepril EP Impurity A (CAS 131064-75-0)
- O-tert-Butyl-dimethylsilyl Curcumin (CAS 911292-36-9)
- (4-Ethoxy-2,6-dimethylphenyl)methanol (CAS 1379225-15-6)
- Diethyl 2-amino-2-methylmalonate hydrochloride (CAS 117610-09-0)
- Fmoc-Dab(Mtt)-OH (CAS 851392-68-2)
- Omeprazole Impurity 17 (CAS CATO-C4X-125517)
- 5-bromo-6-methyl-imidazo[1,5-a]pyridine (CAS 1427326-76-8)
- Semaglutide impurity 87 (CAS CATO-C4X-222687)
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