Docetaxel Impurity 78 CAS 133577-33-0

Description

Compared with other compounds in its class, the molecular weight of 807.88 g/mol gives Docetaxel Impurity 78 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Docetaxel Impurity 78 (CAS 133577-33-0) is a certified pharmaceutical impurity reference standard with the molecular formula C43H53NO14 and a molecular weight of 807.88 g/mol.

The molecular framework of Docetaxel Impurity 78 (C43H53NO14) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Docetaxel Impurity 78 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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