2-Bromo-3-methyl-5-((trimethylsilyl)ethynyl)pyridine CAS 1338492-80-0
| CAS No. | 1338492-80-0 |
| Molecular Formula | C11H14BrNSi |
| Molecular Weight | 268.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Bromo-3-methyl-5-((trimethylsilyl)ethynyl)pyridine (CAS 1338492-80-0), a certified reference material (molecular formula C11H14BrNSi, MW 268.23 g/mol) for analytical method development and quality control.
The molecular framework of 2-Bromo-3-methyl-5-((trimethylsilyl)ethynyl)pyridine (C11H14BrNSi) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Bromo-3-methyl-5-((trimethylsilyl)ethynyl)pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H14BrNSi |
| Molecular Weight | 268.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 2,2,2-Trifluoroethyl n-(1-acetylpiperidin-4-yl)carbamate (CAS 1311316-39-8)
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- Tyrphostin 51 (CAS 126433-07-6)
- 1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-2,2,2-trifluoroethan-1-one (CAS 1354954-37-2)
- 3-(2,6-Dichlorophenyl)-2,6-diphenylpyrimidin-4(3H)-one (CAS 89069-85-2)
- 4XX2ND0257 581-43-1 2,6-Naphthohydroquinone 2,6-Naphthalenediol C.I. 76640 2,6-Dihydroxynaphthalene EINECS 209-465-6 2-Hydroxy-6-naphthol Naphthalene-2,6-diol NSC 62687 UNII-4XX2ND0257 (CAS 581-43-1)
- 1-(2-Chloroethyl)-3-(4-(trifluoromethoxy)phenyl)urea (CAS 937601-75-7)
- Ethyl 2-((5-(3-(trifluoromethyl)phenyl)pyrimidin-2-yl)thio)acetate (CAS 339101-32-5)
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- 5,6-difluoro-1,3-dihydrobenzimidazol-2-one (CAS 176244-21-6)
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- Methyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate hydrochloride (CAS 1052542-93-4)
- 3-(4-Chloro-2-methylbenzenesulfonyl)-4,6-dimethyl-2-(2-methylpropoxy)pyridine (CAS 338774-18-8)
- Insulin Degludec Impurity 1 (CAS 843666-26-2)
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