Dolutegravir Impurity 20 CAS 1341434-11-4
| CAS No. | 1341434-11-4 |
| Molecular Formula | C9H10F2N2 |
| Molecular Weight | 184.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dolutegravir Impurity 20 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dolutegravir Impurity 20 (CAS 1341434-11-4) is a certified pharmaceutical impurity reference standard with the molecular formula C9H10F2N2 and a molecular weight of 184.19 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Dolutegravir Impurity 20 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 184.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dolutegravir Impurity 20 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H10F2N2 |
| Molecular Weight | 184.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Dolutegravir Standards
- Dolutegravir Impurity 14 (CAS 127958-23-0)
- Dolutegravir Impurity 19 (CAS 1916490-96-4)
- Dolutegravir Impurity 27 (CAS 1335210-31-5)
- Dolutegravir Amide (CAS 1485081-26-2)
- Dolutegravir Impurity 67 (CAS CATO-C4X-162067)
- Dolutegravir Impurity N13 (CAS 1246616-73-8)
- Dolutegravir Impurity 51 (CAS CATO-C4X-162051)
- Dolutegravir Impurity 43 (CAS 2651309-06-5)
Recommended Standards
- Propofol Impurity 37 (CAS 494-72-4)
- Oseltamivir Impurity 27 (CAS CATO-C4X-172027)
- Ubidecarenone EP Impurity A (CAS 3066-90-8)
- Tandospirone Impurity 58(Lurasidone Impurity) (CAS 27862-85-7)
- Almotriptan impurity 18 (CAS CATO-C4X-153818)
- Tyr-Deficient lanreotide Impurity (CAS CATO-C4X-23702)
- Ertugliflozin impurity 65 (CAS 1500090-85-6)
- Ethyl 2-((2-(3-chlorophenyl)-6-nitro-1H-benzo[d]imidazol-1-yl)oxy)acetate (CAS 303149-22-6)
- 5-Bromo-6-methoxy-1,3-benzothiazole (CAS 1805151-05-6)
- 2-(1H-Pyrazolo[1,5-b][1,2,4]triazol-2-yl)ethanamine (CAS 197355-77-4)
- 1-(2,5-Dimethylphenyl)but-3-en-1-ol (CAS 1033605-53-6)
- H-Tyr-Lys-Thr-OH (CAS 155943-09-2)
- (5-Bromo-1-methyl-1H-pyrazol-3-yl)methanol (CAS 1782396-26-2)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com