Cefazolin Impurity 57 CAS 134203-48-8
| CAS No. | 134203-48-8 |
| Molecular Formula | C18H27N3O7S |
| Molecular Weight | 429.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Cefazolin Impurity 57 (C18H27N3O7S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Cefazolin Impurity 57 (CAS 134203-48-8, C18H27N3O7S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cefazolin Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H27N3O7S |
| Molecular Weight | 429.49 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Cefazolin Standards
- Cefazolin Impurity 20 (CAS 1798390-47-2)
- Cefazolin EP Impurity B (CAS 2384108-14-7)
- Cefazolin EP Impurity K (Mixture of Diastereomers) (CAS 1322626-65-2)
- Cefazolin Impurity 86 (CAS CATO-C4X-157786)
- Cefazolin EP Impurity K (CAS 2410652-70-7)
- Cefazolin EP Impurity L (CAS CATO-C4X-157710)
- Cefazolin Impurity 41 (CAS CATO-C4X-157741)
- Cefazolin Impurity 42 (CAS 55390-53-9)
Recommended Standards
- Diltiazem Impurity 16 (CAS 3036581-85-5)
- Oxacillin Impurity 3 (CAS CATO-C4X-23213)
- Cefotaxime Impurity 66 (CAS CATO-C4X-120166)
- Oxacillin Impurity 59 (CAS CATO-C4X-232159)
- Fosaprepitant Impurity 18 (CAS 252742-72-6)
- Favipiravir Impurity 2 (CAS 259793-90-3)
- Rosuvastatin Impurity 181 (CAS CATO-C4X-1169181)
- N-Butylacrylamide (stabilized with MEHQ) (CAS 2565-18-6)
- Terbinafine EP Impurity B HCl (CAS 176168-78-8)
- (9H-fluoren-9-yl)methyl (S)-(1-hydroxy-4-phenylbutan-2-yl)carbamate (CAS 1139710-66-9)
- 2-Methyl-N-(3,4,5-trifluorobenzyl)propan-1-amine (CAS 1339450-49-5)
- tert-Butyl (1S,6R)-3,9-diazabicyclo[4.2.1]nonane-3-carboxylate (CAS 1932112-98-5)
- 5-(1-Ethyl-1h-pyrazol-5-yl)-1,2-oxazole-3-carboxylic acid (CAS 1006459-13-7)
- Osteoblast Activating Peptide (mouse, rat) (H-7262.0500) (CAS 1222950-80-2)
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