Fosaprepitant Impurity 18 CAS 252742-72-6
| CAS No. | 252742-72-6 |
| Molecular Formula | C3H4ClN3O |
| Molecular Weight | 133.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C3H4ClN3O, Fosaprepitant Impurity 18 contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 133.54 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Fosaprepitant Impurity 18 (CAS 252742-72-6, C3H4ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Fosaprepitant Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C3H4ClN3O |
| Molecular Weight | 133.54 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 17 (CAS 24021-90-7)
- Fosaprepitant Impurity 36 (CAS 930-63-2)
- Fosaprepitant Impurity 19 (CAS 1623-07-0)
- Fosaprepitant Impurity 41 (CAS 287930-73-8)
- Fosaprepitant Impurity 874 (CAS 538-37-4)
- Fosaprepitant Impurity 41 HCl (CAS 2377328-02-2)
- Fosaprepitant Dimeglumine (CAS 265121-04-8)
- Fosaprepitant Impurity 1 (CAS CATO-C4X-11681)
Recommended Standards
- 5-Chloro-2-methyl-1,2-dihydro-3H-1,2,4-triazol-3-one (CAS 22354-86-5)
- 1-pyrrolidinecarbonyl chloride (CAS 1192-63-8)
- 5-Chloro-1H-1,2,4-triazole-3-methanol (CAS 385377-24-2)
- N-Allyl-2-chloroacetamide (CAS 13269-97-1)
- Drotaverine Impurity 12 (CAS 92157-09-0)
- Azilsartan Impurity 117 (CAS CATO-C4X-1096117)
- Alogliptin Impurity 9 (CAS CATO-C4X-10999)
- 4-Bromo-2-((pyridin-4-ylamino)methyl)phenol (CAS 634594-74-4)
- 2-Bromo-5-((tetrahydro-2H-pyran-4-yl)methyl)pyridine (CAS 2306263-55-6)
- 1-Isobutyl-1H-benzimidazole-2-carbaldehyde (CAS 610275-02-0)
- 【禁售不询】Test Subject 05 (CAS 72-44-6)
- 2-tert-butyl-6-chloropyrimidin-4-amine (CAS 1070217-33-2)
- Diethyl 2-chlorosuccinate (CAS 7209-04-3)
- Characteristic MSH-Tetrapeptide (CAS 4289-02-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com