Regorafenib Impurity 16 CAS 1343498-71-4
| CAS No. | 1343498-71-4 |
| Molecular Formula | C21H15ClF4N4O4 |
| Molecular Weight | 498.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Regorafenib Impurity 16 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 498.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Regorafenib Impurity 16 (CAS 1343498-71-4), a pharmacopoeial impurity reference standard (molecular formula C21H15ClF4N4O4, MW 498.81 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Regorafenib Impurity 16 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H15ClF4N4O4 |
| Molecular Weight | 498.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Regorafenib Standards
- Regorafenib Impurity 13 (CAS 835621-11-9)
- Regorafenib-13C-d3 N-Oxide (CAS 835621-11-9 (Unlabeled))
- Regorafenib Impurity 75 (CAS CATO-C4X-104775)
- Regorafenib-13C-D3 (CAS 2126178-55-8)
- Regorafenib-13C-d3 (CAS 755037-03-7 (Unlabeled))
- Regorafenib D3 (CAS 1255386-16-3)
- Regorafenib Impurity 14 (CAS 835621-12-0)
- Regorafenib (CAS 755037-03-7)
Recommended Standards
- Cholesteryl heptanoate (CAS 1182-07-6)
- N-(2-{[2,5-bis(2,2,2-trifluoroethoxy)phenyl]formamido}ethyl)-4-chlorobenzamide (CAS 338404-42-5)
- 1-(4-Bromophenyl)-2-((5-(4-chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)ethanone (CAS 618432-01-2)
- (3-(4-bromophenoxy)phenyl)(cyano)methyl 2-(4-chlorophenyl)-3-methylbutanoate (CAS 65295-49-0)
- Galanthamine Impurity 25 (CAS CATO-C4X-143525)
- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
- Sulfasalazine Impurity 2 (RRT 0.75) (CAS 139-56-0)
- 2-(Trifluoromethyl)-1,3-benzoxazole-6-carboxylic acid (CAS 1181288-08-3)
- 5-(2-Fluorophenyl)oxazole-4-carboxylic acid (CAS 347187-18-2)
- L-Cysteine, S-[(acetylamino)methyl]-, methyl ester, hydrochloride (1:1) (CAS 33375-68-7)
- Methylene Blue (CAS 61-73-4)
- 4-(((2-Hydroxy-4-methyl-6-oxocyclohex-1-en-1-yl)methylene)amino)-N-(4-methylpyrimidin-2-yl)benzenesulfonamide (CAS 1023576-56-8)
- 2-(2-Phenoxyethoxy)aniline (CAS 114012-05-4)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com