Regorafenib Impurity 15 CAS 1343498-72-5
| CAS No. | 1343498-72-5 |
| Molecular Formula | C20H13ClF4N4O3 |
| Molecular Weight | 468.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Regorafenib Impurity 15 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Regorafenib Impurity 15 (CAS 1343498-72-5, C20H13ClF4N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Regorafenib Impurity 15 (C20H13ClF4N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 468.79 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H13ClF4N4O3 |
| Molecular Weight | 468.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Regorafenib Standards
- Regorafenib Impurity 4 (CAS 1187945-05-6)
- Regorafenib (CAS 755037-03-7)
- Regorafenib Impurity 52 (CAS CATO-C4X-104752)
- Regorafenib Impurity 7 (CAS CATO-C4X-10477)
- Regorafenib Impurity 14 (CAS 835621-12-0)
- Regorafenib D3 (CAS 1255386-16-3)
- Regorafenib-13C-D3 (CAS 2126178-55-8)
- Regorafenib-13C-d3 (CAS 755037-03-7 (Unlabeled))
Recommended Standards
- (1<I>S</I>,2<I>S</I>)-<I>N</I>-<I>p</I>-Tosyl-1,2-dimesitylethylenediamine (CAS 1293946-41-4)
- (6-methyl-3-(4,8,12-trimethyltridecyl)cyclohex-3-en-1-yl)(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)methanone (CAS CATO-C3D-262387)
- (Z)-[(4-Bromophenyl)[2-(4-chlorophenyl)cyclopropyl]methylidene]amino 4-methylbenzoate (CAS 338415-66-0)
- (6-methyl-3-(4,8,12-trimethyltridecyl)cyclohex-3-en-1-yl)(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)methanone (CAS CATO-C3D-262388)
- Darunavir Impurity 39 (CAS CATO-C4X-160639)
- Gliclazide Impurity 1 (CAS 58108-05-7)
- Dotinurad Impurity 158 (CAS CATO-C4X-2494158)
- 2-Methyl-5-(pent-4-enamido)benzoic acid (CAS 1484334-98-6)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com