6-Chloro-8-(trifluoromethyl)chroman-4-one CAS 1344889-75-3
| CAS No. | 1344889-75-3 |
| Molecular Formula | C10H6ClF3O2 |
| Molecular Weight | 250.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Chloro-8-(trifluoromethyl)chroman-4-one (C10H6ClF3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
6-Chloro-8-(trifluoromethyl)chroman-4-one (CAS 1344889-75-3) is a high-purity analytical reference standard with the molecular formula C10H6ClF3O2 and a molecular weight of 250.60 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6ClF3O2 |
| Molecular Weight | 250.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
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Recommended Standards
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- Neodymium(III) chloride (CAS 10024-93-8)
- 2-(Difluoromethyl)-3-methyl-5-nitropyridine-4-carbonyl chloride (CAS 1807145-01-2)
- 9-Hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 123458-49-1)
- (S)-1-(4-ethylphenyl)-2-methylpropan-1-amine (CAS 1213527-77-5)
- Euchrestaflavanone A (CAS 80510-05-0)
- 4-(Chloromethyl)-5-methyl-2-(3-phenoxyphenyl)oxazole (CAS 1048921-12-5)
- Posaconazole Impurity 11 (CAS 159811-30-0)
- 171204-19-6 4-Quinolinecarboxylic acid, 2-((2,4-dimethylphenyl)amino)- 2-((2,4-Dimethylphenyl)amino)-4-quinolinecarboxylic acid (CAS 171204-19-6)
- 2-Chloro-5-((4-(pyridin-2-yl)piperazin-1-yl)methyl)thiazole (CAS 865660-09-9)
- Torasemide Impurity 9 (CAS 110363-51-4)
- 4-Methyl-3,5-bis(pyridin-4-yl)benzoic acid (CAS 2241495-55-4)
- Neuropeptide Y (2-36), amide, porcine (CAS 102961-52-4)
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