Nebivolol Impurity 105 CAS 1345202-53-0
| CAS No. | 1345202-53-0 |
| Molecular Formula | C20H21FO6S |
| Molecular Weight | 408.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Nebivolol Impurity 105 (CAS 1345202-53-0, C20H21FO6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nebivolol Impurity 105 (C20H21FO6S) is characterized by a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Nebivolol Impurity 105 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H21FO6S |
| Molecular Weight | 408.44 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 50 (CAS CATO-C4X-196850)
- rac Nebivolol-d4 (CAS 1219407-55-2)
- Nebivolol Impurity 12（RS,SR） (CAS 119365-30-9)
- Nebivolol Impurity 13（SR,SR） (CAS CATO-C4X-196813)
- Nebivolol Impurity 19 (CAS CATO-C4X-196819)
- Nebivolol Impurity 3（RR,SS） (CAS 1360598-84-0)
- L-Nebivolol (RS,SS) (CAS 118457-16-2)
- Nebivolol Impurity 31（RR,SR）or（RS,RR） (CAS 119365-26-3)
Recommended Standards
- Xanthone I (CAS 35349-68-9)
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- ISPA-28 (CAS 1006335-39-2)
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- Voriconazole Impurity 80 (CAS 188416-47-9)
- Labetalol Impurity 49 (CAS CATO-C4X-246649)
- Alendronic Acid Impurity 5 (CAS CATO-C4X-22425)
- tert-butyl N-[2-amino-1-(2,4-difluorophenyl)ethyl]carbamate (CAS 1016680-39-9)
- (9H-Fluoren-9-yl)methyl (S)-(4-hydroxybutan-2-yl)carbamate (CAS 1221274-40-3)
- Methyl 4-(1-hydroxypropyl)-1-methyl-1H-pyrrole-2-carboxylate (CAS 1135283-27-0)
- 2-Hydrazono-1,3-dimethyl-2,3-dihydro-1H-imidazole (CAS 461388-49-8)
- (3R,3aS,6R,6aS)-Hexahydrofuro[3,2-b]furan-3,6-diamine (CAS 143396-58-1)
- 2-(1,3-Benzodioxol-5-yl)-6-chloroquinoline-4-carbonyl chloride (CAS 1160263-50-2)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com