rac Nebivolol-d4 CAS 1219407-55-2
| CAS No. | 1219407-55-2 |
| Molecular Formula | - |
| Molecular Weight | 409.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
rac Nebivolol-d4 (CAS 1219407-55-2), molecular formula C22H21D4F2NO4 and molecular weight 409.46 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of rac Nebivolol-d4 (C22H21D4F2NO4) is characterized by deuterium isotope labeling, a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21D4F2NO4 |
| Molecular Weight | 409.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related rac Standards
- Nebivolol Impurity 105 (CAS 1345202-53-0)
- Nebivolol Impurity 50 (CAS CATO-C4X-196850)
- Nebivolol-D6 (CAS 99200-09-6 (unlabeled))
- Nebivolol Impurity 12（RS,SR） (CAS 119365-30-9)
- Nebivolol Impurity 13（SR,SR） (CAS CATO-C4X-196813)
- Nebivolol Impurity 19 (CAS CATO-C4X-196819)
- Nebivolol Impurity 3（RR,SS） (CAS 1360598-84-0)
- L-Nebivolol (RS,SS) (CAS 118457-16-2)
Recommended Standards
- (S,R,R,R)-Nebivolol D4 (CAS 118457-15-1(Unlabelled))
- Boc-His(1-Tos)-OH (CAS 35899-43-5)
- (R,S,S,S)-Nebivolol D4 (CAS CATO-C4X-196887)
- (2R,4R)-1-Fmoc-4-(tert-butoxy)pyrrolidine-2-carboxylic Acid (CAS 1276694-30-4)
- 58794-09-5 7-BROMOISOQUINOLINE ABBYPHARMA AP-30-0996 BC003691 ISOQUINOLINE, 7-BROMO- (CAS 58794-09-5)
- Iosericacid (CAS 51876-99-4)
- 12-Methyltridecanol (CAS 21987-21-3)
- 2-Chloro-6,7-dimethoxyquinoline (CAS 68236-22-6)
- 2-Bromo-6-methoxy-4-methylquinazoline (CAS 1783600-59-8)
- 3-Amino-3-methyl-butyric acid ethyl ester (CAS 85532-42-9)
- Nintedanib Impurity 61 (CAS 2117628-65-4)
- 3-Phenylisoxazol-5(4H)-imine (CAS 90417-07-5)
- 4-Methyl-4'-(pyrrolidin-1-ylsulfonyl)-[1,1'-biphenyl]-3-ol (CAS 1261923-32-3)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com