Domperidone EP Impurity E CAS 1346602-50-3
| CAS No. | 1346602-50-3 |
| Molecular Formula | C32H34ClN7O3 |
| Molecular Weight | 600.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Domperidone EP Impurity E (C32H34ClN7O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Domperidone EP Impurity E (CAS 1346602-50-3) is a certified pharmaceutical impurity reference standard with the molecular formula C32H34ClN7O3 and a molecular weight of 600.11 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C32H34ClN7O3 |
| Molecular Weight | 600.11 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Domperidone Standards
- Domperidone EP Impurity D (CAS 1614255-34-3)
- Domperidone Impurity 41 (CAS CATO-C4X-142041)
- Domperidone EP Impurity F (CAS 1391053-55-6)
- Domperidone Impurity 40(1s,4r) (CAS CATO-C4X-142040)
- rac-Domperidone EP Impurity C (Domperidone N-Oxide) (CAS 118435-03-3)
- Domperidone-D6 (CAS 1329614-18-7)
- Domperidone (CAS 57808-66-9)
- Domperidone Impurity 32 (CAS CATO-C4X-142032)
Recommended Standards
- Venetoclax Impurity 27 (CAS CATO-C4X-249527)
- 1H,1h-perfluoro-1-dodecanol (CAS 423-65-4)
- 1-Trifluoroacetyl-3,5-bis(nonafluorobutyl)pyrazole (CAS 261761-06-2)
- 3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (CAS 1936529-65-5)
- Diquafosol Impurity 5 (CAS CATO-C4X-21495)
- Mesalazine EP Impurity E (CAS 65-49-6)
- Glucuronic Acid impurity 3 (CAS CATO-C4X-25513)
- (2-(Propylcarbamoyl)phenyl)boronic acid (CAS 874459-87-7)
- 1-((4-Chlorophenyl)sulfonyl)piperidin-4-one (CAS 156634-92-3)
- (4E)-4-[2-(4-Chlorophenyl)hydrazin-1-ylidene]-2-methyl-1,2,3,4-tetrahydroisoquinoline-1,3-dione (CAS 97458-94-1)
- 2-(3-Nitrophenyl)hexahydrobenzo[d][1,3]dioxole (CAS 1087725-58-3)
- Tolterodine Impurity N4 (CAS 173948-30-6)
- 5-fluoro-3-methyl-3H-isobenzofuran-1-one (CAS 2231233-89-7)
- Semaglutide impurity 93 (CAS CATO-C4X-222693)
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