Bupropion Impurity 20 CAS 1346603-00-6
| CAS No. | 1346603-00-6 |
| Molecular Formula | C13H17Cl2NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Bupropion Impurity 20 (C13H17Cl2NOHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Bupropion Impurity 20 (CAS 1346603-00-6, C13H17Cl2NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H17Cl2NO HCl |
| Molecular Weight | 310.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bupropion Standards
- Bupropion Impurity 72 (CAS 102141-11-7)
- Bupropion Impurity 71 (CAS 102141-12-8)
- Bupropion Impurity 9 (CAS 103175-61-7)
- Bupropion Hydrochloride USP Related Compound B (CAS 1049718-43-5)
- Bupropion Hydrochloride USP Related Compound A (CAS 1049718-72-0)
- Bupropion impurity 67 (CAS 1049974-40-4)
- Bupropion Impurity 17 (CAS 10557-17-2)
- Bupropion Morpholinol Impurity (HCl Salt) (CAS 106083-71-0)
Recommended Standards
- Gadobutrol Impurity 118 (CAS CATO-C4X-2120118)
- Salicylic Acid Impurity 4 (CAS CATO-C4X-19024)
- Tiotropium Impurity 34 (CAS 169219-67-4)
- 4-(3-(1-Ethylpyrrolidin-2-yl)pyridin-2-yl)morpholine (CAS 1352519-03-9)
- N-(3-Chlorophenyl)pyrrolidine-1-carboxamide (CAS 35640-07-4)
- Dimethyl 2-fluorobiphenyl-3,3'-dicarboxylate (CAS 1381944-85-9)
- 4-(Bromomethyl)-N,N-diphenylbenzenamine (CAS 183994-94-7)
- Methyl 2-(methylamino)-1,3-thiazole-5-carboxylate (CAS 1384661-33-9)
- {2-amino-1-[4-(propan-2-yloxy)phenyl]ethyl}dimethylamine (CAS 928000-64-0)
- D-Ala35-Tirzepatide (CAS CATO-CPTD788904)
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