Clodronate Disodium EP Impurity D CAS 87591-00-2
| CAS No. | 87591-00-2 |
| Molecular Formula | CH5ClO6P2 |
| Molecular Weight | 210.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clodronate Disodium EP Impurity D is closely related to a phosphate ester group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Clodronate Disodium EP Impurity D (CAS 87591-00-2) is a certified pharmaceutical impurity reference standard with the molecular formula CH5ClO6P2 and a molecular weight of 210.45 g/mol.
The molecular framework of Clodronate Disodium EP Impurity D (CH5ClO6P2) is characterized by a phosphate ester group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | CH5ClO6P2 |
| Molecular Weight | 210.45 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | -1.0 |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
Related Clodronate Standards
Recommended Standards
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- 2,6-Dichloroquinone-4-chloroimide (CAS 101-38-2)
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- 6H-Benzo[c]chromen-1-ol (CAS 185613-45-0)
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- Tanshindiol A (CAS 97411-46-6)
- 1-Bromo-7-fluoroisoquinoline (CAS 1207448-24-5)
- Resmetirom impurity 122 (CAS 2639977-02-7)
- Tirzepatide Impurity 19 X TFA Salt (CAS CATO-C4X-324019)
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