Ioversol Impurity 1 CAS 134768-85-7
| CAS No. | 134768-85-7 |
| Molecular Formula | C15H18I3N3O7 |
| Molecular Weight | 733.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 733.03 g/mol gives Ioversol Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ioversol Impurity 1 (CAS 134768-85-7, C15H18I3N3O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ioversol Impurity 1 (C15H18I3N3O7) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ioversol Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H18I3N3O7 |
| Molecular Weight | 733.03 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 3 |
Related Ioversol Standards
- Ioversol impurity 34 (CAS CATO-C4X-209134)
- Ioversol Impurity 13 (CAS 2253945-67-2)
- Ioversol Impurity 7 (CAS CATO-C4X-209137)
- Ioversol Impurity 24 (CAS CATO-C4X-209124)
- Ioversol Hydrolyzate(N-Desmethyl Iomeprol) (CAS 77868-40-7)
- Ioversol impurity 35 (CAS CATO-C4X-209135)
- Ioversol impurity 30 (CAS CATO-C4X-209130)
- Ioversol Impurity 8 (CAS 134768-83-5)
Recommended Standards
- VYL51769RX 3806-34-6 Distearyl pentaerythritol diphosphite O,O'-Dioctadecylpentaerythritol bis(phosphite) 2,4,8,10-Tetraoxa-3,9-diphosphaspiro(5.5)undecane, 3,9-bis(octadecyloxy)- EINECS 223-276-6 HSDB 7257 UNII-VYL51769RX EC 223-276-6 (CAS 3806-34-6)
- Iobitridol Impurity 5 (CAS CATO-C4X-31785)
- Azithromycin EP Impurity B (CAS 307974-61-4)
- 3,3'',5,5''-Tetra-tert-butyl-5'-(3,5-di-tert-butyl-4-hydroxyphenyl)-2',4',6'-trimethyl-[1,1':3',1''-terphenyl]-4,4''-diol (CAS 23422-38-0)
- Perospirone Impurity 47 (CAS CATO-C4X-245847)
- Palbociclib Impurity 140 (CAS CATO-C4X-1125140)
- Vericiguat Impurity 66 (CAS CATO-C4X-289666)
- 2-(Allyloxy)-4-methoxybenzyl Chloride (CAS 1823868-00-3)
- n-((Tetrahydrofuran-2-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 838902-19-5)
- (E)-3-(2,4-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one (CAS 64200-22-2)
- (E)-[2-(4-Chlorobenzenesulfonyl)ethylidene][(2,6-dichlorophenyl)methoxy]amine (CAS 338395-19-0)
- (1S)-1-(4-bromophenyl)-2-chloroethanol (CAS 1076233-87-8)
- (3-Ethoxy-4-((4-fluorobenzyl)oxy)phenyl)methanol (CAS 861433-56-9)
- MOTS-c Peptide (CAS 1627580-64-6)
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