Gemcitabine Impurity 28 CAS 134790-40-2
| CAS No. | 134790-40-2 |
| Molecular Formula | C23H19F2N3O6 |
| Molecular Weight | 471.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Gemcitabine Impurity 28.
CATO supplies Gemcitabine Impurity 28 (CAS 134790-40-2), a pharmacopoeial impurity reference standard (molecular formula C23H19F2N3O6, MW 471.41 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Gemcitabine Impurity 28 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 471.41 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H19F2N3O6 |
| Molecular Weight | 471.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Gemcitabine Standards
- Gemcitabine Impurity 11 (CAS 134790-39-9)
- Gemcitabine Impurity 16 (CAS CATO-C4X-137216)
- Gemcitabine Impurity 27 (CAS 1268237-46-2)
- Gemcitabine Impurity 38 (CAS CATO-C4X-137238)
- Gemcitabine Impurity 30 (CAS 143157-27-1)
- Gemcitabine Impurity 34 (CAS CATO-C4X-137234)
- Gemcitabine Impurity 35 (CAS CATO-C4X-137235)
- Gemcitabine Impurity 10 (CAS 122111-11-9)
Recommended Standards
- (2S)-2-(4-(3-Amino-1,9-dioxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid (CAS 10538-99-5)
- (R,S)-Norfluoxetine N-β-D-glucuronide (CAS 96735-72-7)
- N-(2-bromophenyl)-2-((5-cyclohexyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332872-86-3)
- 3-(Trifluoromethyl)-N-(4-(((3-(trifluoromethyl)phenyl)sulfinyl)methyl)phenyl)benzamide (CAS 477710-63-7)
- Prucalopride Impurity 48 (CAS 137211-63-3)
- Posaconazole Impurity 124 (CAS 2134652-05-2)
- Entacapone EP Impurity B (CAS 1215039-66-9)
- Ethyl 7-bromo-3,4-dihydro-4-oxoquinoline-3-carboxylate, 97% (CAS 1116339-64-0)
- (2E)-1-(3-Bromophenyl)-3-(4-ethylphenyl)prop-2-en-1-one (CAS 940809-51-8)
- Trazodone Impurity 102 (CAS CATO-C4X-1772102)
- 6-Bromobenzo[d]isothiazole (CAS 877265-23-1)
- 2-((5-(4-Methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N,N-diphenylacetamide (CAS 332385-00-9)
- 4-Methylenecyclohexane-1-carboxamide (CAS 1420294-77-4)
- D-Thr5-Tirzepatide (CAS CATO-CPTD788926)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com