Entacapone EP Impurity B CAS 1215039-66-9
| CAS No. | 1215039-66-9 |
| Molecular Formula | C12H10N2O6 |
| Molecular Weight | 278.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Entacapone EP Impurity B.
Entacapone EP Impurity B (CAS 1215039-66-9) is a certified pharmaceutical impurity reference standard with the molecular formula C12H10N2O6 and a molecular weight of 278.22 g/mol.
The molecular framework of Entacapone EP Impurity B (C12H10N2O6) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10N2O6 |
| Molecular Weight | 278.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Entacapone Standards
- Entacapone Impurity 01 (CAS 116314-52-4)
- Entacapone Impurity 2 (CAS 150995-46-3)
- Entacapone Impurity 36 (CAS CATO-C4X-162936)
- Entacapone Impurity 72 (CAS 893419-47-1)
- Entacapone impurity 52 (CAS CATO-C4X-162952)
- Entacapone Impurity 12 (CAS CATO-C4X-162912)
- Entacapone EP Impurity I (CAS 1364322-42-8)
- Entacapone impurity 18 (CAS CATO-C4X-162918)
Recommended Standards
- Tert-butyl (4,4,5,5,5-pentafluoropentyl) carbonate (CAS 1980038-99-0)
- Varenicline Impurity 12 (CAS CATO-C4X-196212)
- Methyl 3-[Hydroxy(4-nitrophenyl)methyl]isoxazole-4-carboxylate (CAS 2006277-45-6)
- Varenicline Impurity 36 (CAS CATO-C4X-196237)
- Relebactam Impurity 64 (CAS CATO-C4X-214464)
- Etrasimod impurity 1 (CAS 1206123-36-5)
- Sorafenib Impurity 41 (CAS 1129683-83-5)
- (1R,3r)-N-isopropyl-3-methoxycyclobutan-1-amine (CAS 2154724-18-0)
- 4-[(4-bromophenyl)methoxy]phenyl benzoate (CAS 1803582-87-7)
- Boc-Tyr(Allyl)-OH (CAS 127132-38-1)
- N-(2-Methoxyethyl)-2-(5-oxo-5,6-dihydro-4H-imidazo[1,2-b][1,2,4]triazol-6-yl)acetamide (CAS 1428139-11-0)
- 7-Methyl-4,4a,5,6-tetrahydronaphthalen-2(3H)-one (CAS 34545-88-5)
- Methyl 3-phenyl-2-(pyridin-2-yl)propanoate (CAS 4558-90-1)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
Why CATO?
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