N-(5-Chloro-2-methylphenyl)-3-hydroxy-2-naphthylcarboxamide CAS 135-63-7
| CAS No. | 135-63-7 |
| Molecular Formula | C18H14ClNO2 |
| Molecular Weight | 311.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 311.76 g/mol gives N-(5-Chloro-2-methylphenyl)-3-hydroxy-2-naphthylcarboxamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies N-(5-Chloro-2-methylphenyl)-3-hydroxy-2-naphthylcarboxamide (CAS 135-63-7), a certified reference material (molecular formula C18H14ClNO2, MW 311.76 g/mol) for analytical method development and quality control.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, N-(5-Chloro-2-methylphenyl)-3-hydroxy-2-naphthylcarboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 311.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H14ClNO2 |
| Molecular Weight | 311.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related N Standards
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- 4-Chloro-6,7-bis(2-methoxyethoxy)quinoline (CAS 1137579-56-6)
- 3-Acetyl-6-chloro-4-(4-methylphenyl)quinolin-2(1H)-one (CAS 1283108-80-4)
- Ethyl 6-chloro-4-phenylquinoline-3-carboxylate (CAS 128832-35-9)
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Recommended Standards
- Lifitegrast Impurity 130 (CAS CATO-C4X-2409130)
- Triadimenol-tert-butylhydroxy (CAS 72699-18-4)
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- 2-(tert-butoxycarbonyl)-7-chloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid (CAS CATO-CIM-105789)
- 1-Isopropyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine (CAS 1536171-80-8)
- 6-Bromo-N-cyclobutylpyridin-2-amine (CAS 959237-26-4)
- 5-(4-Fluorophenyl)nicotinonitrile (CAS 154237-18-0)
- 5-Bromo-2-(2-(difluoromethoxy)-7-methylquinoxalin-5-yl)thiazole (CAS 2172977-41-0)
- 3'-Bromo-4-fluoro-3,5-dimethyl-1,1'-biphenyl (CAS 1443314-03-1)
- Ethyl 4-(acetylamino)-3-nitrobenzoate (CAS 175204-17-8)
- 6-Amino-9-butyl-9H-purine-8-sulfonic acid (CAS 1387557-30-3)
- 3-Methoxy-4-methyl-1H-pyrrole (CAS 29206-35-7)
- (2S,5S)-1-Hydroxy-2,5-diphenylphospholane 1-oxide (CAS 474049-73-5)
- [y-Glu3]-Semaglutide Impurity 135 (CAS CATO-C4X-2226135)
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