Tofacitinib Impurity 108 DiHCl CAS 1354486-07-9
| CAS No. | 1354486-07-9 |
| Molecular Formula | C14H22N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 108 DiHCl.
Tofacitinib Impurity 108 DiHCl (CAS 1354486-07-9) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22N2HCl and a molecular weight of 254.80 g/mol.
Based on its molecular formula C14H22N2HCl, Tofacitinib Impurity 108 DiHCl contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 254.80 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H22N2 2*HCl |
| Molecular Weight | 254.80 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Fulvestrant Impurity 9 (CAS 55362-80-6)
- Oseltamivir Impurity 168 (CAS CATO-C4X-1720168)
- Evocalcet impurity 57 (CAS CATO-C4X-248557)
- 3-Bromo-7-fluoro-5-methoxy-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide (CAS 2100839-76-5)
- 5-Bromo-1-phenyl-1h-pyrazole (CAS 17635-42-6)
- 2-Bromo-4-iodoanisole (CAS 182056-39-9)
- Ethyl 2-(cyclopropanecarbonyl)-3,3,3-trifluoropropanoate (CAS 1502216-04-7)
- (2-(2-Ethylphenyl)cyclopropyl)methanol (CAS 1517037-41-0)
- N1-(Pyridin-3-yl)-N2-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)oxalamide (CAS 1251577-02-2)
- C-Peptide 2 (rat) (CAS 41594-08-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com