Tofacitinib Impurity 133 CAS 10132-07-7
| CAS No. | 10132-07-7 |
| Molecular Formula | C4H3Cl2N3 |
| Molecular Weight | 163.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Tofacitinib Impurity 133 (CAS 10132-07-7) is a certified pharmaceutical impurity reference standard with the molecular formula C4H3Cl2N3 and a molecular weight of 163.99 g/mol.
Based on its molecular formula C4H3Cl2N3, Tofacitinib Impurity 133 contains a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 163.99 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H3Cl2N3 |
| Molecular Weight | 163.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tofacitinib Standards
- Tofacitinib Impurity 82 (CAS 1229041-97-7)
- Tofacitinib Impurity 29 (CAS 90953-01-8)
- Tofacitinib Impurity 52 (CAS 694495-63-1)
- Tofacitinib Impurity 206 (CAS CATO-C4X-1079206)
- Tofacitinib Impurity 140 (CAS CATO-C4X-1079140)
- Tofacitinib Impurity 220 (CAS 1279816-72-6)
- Tofacitinib Impurity 192 (CAS CATO-C4X-1079192)
- Tofacitinib Impurity 196 (CAS CATO-C4X-1079196)
Recommended Standards
- 5-Amino-2,4-dichloropyrimidine (CAS 5177-27-5)
- Vonoprazan Impurity N3 (CAS 15177-57-8)
- 5,6-Dichloropyrazin-2-amine (CAS 59489-29-1)
- 4-Bromobut-2-enamide (CAS 118941-93-8)
- Cytarabine Impurity 4 (CAS 408531-05-5)
- Melitracen Impurity 6 (CAS 18792-73-9)
- Rupatadine Impurity 24 (CAS 100910-66-5)
- Benzyl 3-oxo-2,4-diazabicyclo[3.1.0]hexane-2-carboxylate (CAS 68982-22-9)
- Rac Ibuprofen-d3 (CAS 121662-14-4)
- 2-Amino-4-(aminooxy)butanoic acid (CAS 15985-61-2)
- 110170-37-1 4-Galloylquinic acid (CAS 110170-37-1)
- (S)-3-Methylcyclohexanone (CAS 24965-87-5)
- (5-Oxaspiro[3.5]Nonan-8-yl)methanol (CAS 1501084-95-2)
- (Leu31,Pro3?)-Neuropeptide Y (porcine) trifluoroacetate salt (CAS 125580-28-1)
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