Cabazitaxel Impurity N1 CAS 1354900-66-5
| CAS No. | 1354900-66-5 |
| Molecular Formula | C53H63NO15 |
| Molecular Weight | 954.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Cabazitaxel Impurity N1 (C53H63NO15) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Cabazitaxel Impurity N1 (CAS 1354900-66-5, C53H63NO15) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C53H63NO15 |
| Molecular Weight | 954.07 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 23.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Cabazitaxel Standards
- Cabazitaxel Impurity 38 (CAS CATO-C4X-111538)
- Cabazitaxel Impurity 39 (CAS CATO-C4X-111539)
- Cabazitaxel Impurity 40 (CAS CATO-C4X-111540)
- Cabazitaxel Impurity 41 (CAS CATO-C4X-111541)
- Cabazitaxel Impurity 42 (CAS CATO-C4X-111542)
- Cabazitaxel Impurity 49 (CAS CATO-C4X-111549)
- Cabazitaxel Impurity 51 (CAS 1446010-46-3)
- Cabazitaxel Impurity 7 (CAS CATO-C4X-11157)
Recommended Standards
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