Gadobutrol impurity 163 CAS 1360544-74-6
| CAS No. | 1360544-74-6 |
| Molecular Formula | C16H25N4O8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Gadobutrol impurity 163 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Gadobutrol impurity 163 (CAS 1360544-74-6, C16H25N4O8Fe) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Gadobutrol impurity 163 (C16H25N4O8Fe) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.5, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 457.24 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Gadobutrol impurity 163 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H25N4O8 Fe |
| Molecular Weight | 457.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 4 |
Related Gadobutrol Standards
- Gadobutrol Impurity 112 (CAS 1003-83-4)
- Gadobutrol Impurity 12 4HCl (CAS 10045-25-7)
- Gadobutrol Impurity 79 (CAS 105855-71-8)
- Gadobutrol Impurity 115 (CAS 112-24-3)
- Gadobutrol EP Impurity C (Gadoteridol USP Related Compound B) (CAS 112188-16-6)
- Gadobutrol Impurity N5 (CAS 112193-75-6)
- Gadobutrol Impurity 104 4HCl (CAS 112193-75-6（free base）)
- Gadobutrol Impurity 37 (Cyclen Disulfate) (CAS 112193-77-8)
Recommended Standards
- Bortezomib Impurity 65 (CAS CATO-C4X-107265)
- Cefixime Impurity 104 (CAS 101156-41-6)
- Phenylephrine Impurity 78 (CAS CATO-C4X-146778)
- (2-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)pyridin-4-yl)methanol (CAS 1806844-67-6)
- 2-Chloro-6-fluoroisonicotinic Acid (CAS 1211521-09-3)
- 2-(Bicyclo[2.2.1]heptan-2-yl)ethan-1-amine hydrochloride (CAS 90949-05-6)
- Oxcarbazepine Impurity 40 (CAS 186694-45-1)
- Budesonide EP Impurity K (Mixture of Epimer) (CAS 51333-05-2)
- Miboplatin (CAS 103775-75-3)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com