Phenylephrine Impurity 78 CAS CATO-C4X-146778
| CAS No. | CATO-C4X-146778 |
| Molecular Formula | C8H9BrO2 |
| Molecular Weight | 217.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Phenylephrine Impurity 78 (CAS CATO-C4X-146778, C8H9BrO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system, Phenylephrine Impurity 78 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 217.06 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9BrO2 |
| Molecular Weight | 217.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Phenylephrine Standards
- Phenylephrine Impurity 45 (CAS 2491-37-4)
- Phenylephrine Impurity 89 (CAS CATO-C4X-146789)
- Phenylephrine Related Compound G (CAS 1094089-46-9)
- Phenylephrine Impurity 68 (CAS CATO-C4X-146768)
- Phenylephrine Impurity 69 (CAS CATO-C4X-146769)
- Phenylephrine Impurity 70 (CAS CATO-C4X-146770)
- Phenylephrine Impurity 25 (CAS 85299-04-3)
- Phenylephrine Impurity 33 (CAS CATO-C4X-146733)
Recommended Standards
- (4-bromo-1,3-phenylene)dimethanol (CAS CATO-C3D-263171)
- 1-Bromo-3,5-dimethoxybenzene (CAS 20469-65-2)
- 1-Bromo-2,4-dimethoxybenzene (CAS 17715-69-4)
- 1-Bromo-2,5-dimethoxybenzene (CAS 25245-34-5)
- Terazosin Impurity 23 (CAS 1260939-66-9)
- Atorvastatin Impurity 55 (CAS 196085-84-4)
- Relugolix Impurity 20 (CAS CATO-C4X-242920)
- 1,1,1,2,2,3,3-Heptafluoro-3-methoxypropane (CAS 375-03-1)
- 1-(4-Hydroxyphenyl)piperazine (CAS 56621-48-8)
- (1S)-1-phenylpropane-1,3-diamine (CAS 208655-12-3)
- N-(Benzo[d][1,3]dioxol-5-yl)-1,2,5-thiadiazole-3-carboxamide (CAS 342013-70-1)
- Phenylhydrazine oxalate (CAS 37887-33-5)
- 4-chloro-6-iodo-pyrimidine (CAS 258506-74-0)
- KALA Amphipathic Peptide (CAS 187987-64-0)
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