Azilsartan Impurity 9 CAS 136285-69-3
| CAS No. | 136285-69-3 |
| Molecular Formula | C23H21N3O2 |
| Molecular Weight | 371.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Azilsartan Impurity 9 (CAS 136285-69-3, C23H21N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Azilsartan Impurity 9 (C23H21N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H21N3O2 |
| Molecular Weight | 371.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 3 |
Related Azilsartan Standards
- Azilsartan impurity 141 (CAS CATO-C4X-1096141)
- Azilsartan Impurity 131 (CAS CATO-C4X-1096131)
- Azilsartan Impurity 19 (CAS 1993494-84-0)
- Azilsartan Impurity 89 (CAS 147404-75-9)
- Azilsartan Impurity 158 (CAS 183986-64-3)
- Azilsartan Impurity 112 (CAS CATO-C4X-1096112)
- Azilsartan Impurity 74 (CAS 139481-33-7)
- Azilsartan Impurity 130 (CAS CATO-C4X-1096130)
Recommended Standards
- Mivacurium chloride Impurity 27 (CAS 61349-11-9)
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- tert-butyl 3-((quinoxalin-2-ylmethyl)carbamoyl)tetrahydropyrimidine-1(2H)-carboxylate (CAS CATO-C3D-262770)
- Elagolix Impurity 44 (CAS 2316733-81-8)
- Trelagliptin Impurity 54 (CAS 1261686-95-6)
- Ensifentrine Impurity 3 (CAS 3067475-18-4)
- 3-(4-Chlorophenyl)-2-piperazinone (CAS 86147-28-6)
- 2-(Benzyl(methyl)amino)-6-methylnicotinonitrile (CAS 1283472-64-9)
- Cyclopent-2-ene-1-carboxylic acid (CAS 2348-89-2)
- Ethyl 3-(4-Bromophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylate (CAS 1159978-86-5)
- 1-(4-Chlorophenyl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one (CAS 934022-20-5)
- 4-Benzyl-5-ethoxy-1H-imidazole (CAS 239124-59-5)
- Retatrutide (CAS 2381089-83-2)
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