Pranlukast Impurity 1 CAS 136450-10-7
| CAS No. | 136450-10-7 |
| Molecular Formula | C27H24N2O5 |
| Molecular Weight | 456.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Pranlukast Impurity 1 (C27H24N2O5) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Pranlukast Impurity 1 (CAS 136450-10-7, C27H24N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pranlukast Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H24N2O5 |
| Molecular Weight | 456.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 2 |
Related Pranlukast Standards
- Pranlukast Impurity 2 (CAS 211116-98-2)
- Pranlukast Impurity N1 (CAS 136450-11-8)
- Pranlukast (CAS 103177-37-3)
- Pranlukast Impurity 5 (CAS CATO-C4X-18045)
- Pranlukast impurity 12 (CAS CATO-C4X-180412)
- Pranlukast Impurity 11 (CAS 136450-05-0)
- Pranlukast Impurity 6 (CAS CATO-C4X-18046)
- Pranlukast Impurity 10 (CAS CATO-C4X-180410)
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