Pranlukast impurity 12 CAS CATO-C4X-180412
| CAS No. | CATO-C4X-180412 |
| Molecular Formula | C17H17ClO2 |
| Molecular Weight | 288.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Pranlukast impurity 12 (CAS CATO-C4X-180412) is a certified pharmaceutical impurity reference standard with the molecular formula C17H17ClO2 and a molecular weight of 288.77 g/mol.
The molecular framework of Pranlukast impurity 12 (C17H17ClO2) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H17ClO2 |
| Molecular Weight | 288.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Pranlukast Standards
- Pranlukast Impurity 11 (CAS 136450-05-0)
- Pranlukast Impurity 10 (CAS CATO-C4X-180410)
- Pranlukast Impurity 8 (CAS CATO-C4X-18048)
- Pranlukast Impurity 5 (CAS CATO-C4X-18045)
- Pranlukast Impurity 7 (CAS CATO-C4X-18047)
- Pranlukast Impurity 3 (CAS 70977-72-9)
- Pranlukast Impurity N1 (CAS 136450-11-8)
- Pranlukast Impurity 1 (CAS 136450-10-7)
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- N-((2R,3R,4R,5R)-3,4,5-trihydroxy-1-oxohexan-2-yl)acetamide (CAS 200272-62-4)
- 3-Ethoxy-1,1,1-trifluorobutan-2-ol (CAS 367-13-5)
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