Tiotropium Bromide EP Impurity I CAS 136521-48-7
| CAS No. | 136521-48-7 |
| Molecular Formula | C19H22NO4S2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Tiotropium Bromide EP Impurity I (CAS 136521-48-7, C19H22NO4S2Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tiotropium Bromide EP Impurity I (C19H22NO4S2Br) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H22NO4S2 Br |
| Molecular Weight | 472.41 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Tiotropium Standards
- Tiotropium Impurity 26 (CAS 10299-90-8)
- Tiotropium Bromide Impurity 8 Potassium Salt (CAS 10304-09-3)
- Tiotropium Bromide EP Impurity H (Mixture of Enantiomers) (CAS 1044148-31-3)
- Tiotropium Bromide EP Impurity H-d3 Bromide (Mixture of Enantiomers) (CAS 1044148-31-3（unlabeled）)
- Tiotropium-d6 (CAS 1126775-44-7)
- Tiotropium-D3 Bromide (CAS 1127226-56-5)
- Tiotropium Bromide EP Impurity B (CAS 136310-64-0)
- Tiotropium EP Impurity D (CAS 136310-66-2)
Recommended Standards
- Tadalafil Impurity N98 (CAS 1795790-92-9)
- Cefdinir CP Impurity A (CAS 1450758-21-0)
- Rimegepant Impurity 152 (CAS CATO-C4X-2487152)
- 2,4-Difluoro-6-(methyl)thiophenol (CAS 1805063-31-3)
- 6-Methyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid (CAS 1638763-82-2)
- 1-Tert-butyl 4-ethyl 3-oxoazepane-1,4-dicarboxylate (CAS 98977-38-9)
- 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4-diamine (CAS 1854-47-3)
- 1-Bromohenicosafluorodecane (CAS 307-43-7)
- N-(5-Amino-2-methoxyphenyl)cyclopentanecarboxamide (CAS 926269-06-9)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com