Bendamustine Impurity 27 CAS 1366085-72-4
| CAS No. | 1366085-72-4 |
| Molecular Formula | C16H23N3O3 |
| Molecular Weight | 305.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Bendamustine Impurity 27 (CAS 1366085-72-4, C16H23N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H23N3O3, Bendamustine Impurity 27 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 305.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H23N3O3 |
| Molecular Weight | 305.37 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 3 |
Related Bendamustine Standards
- Bendamustine Nitro Isopropyl Ester Impurity (CAS 1374784-01-6)
- Bendamustine Impurity 25 (CAS 3543-76-8)
- Bendamustine Impurity 13 (CAS 1228552-02-0)
- Bendamustine Nitro Ethyl Ester Impurity (CAS 3543-72-4)
- Bendamustine USP Related Compound A (CAS 109882-30-6)
- Bendamustine Impurity 35 (CAS CATO-C4X-127135)
- Bendamustine Impurity 25 (CAS 91644-13-2)
- Bendamustine Impurity 37 (CAS CATO-C4X-127137)
Recommended Standards
- tert-butyl (2-(2-((tert-butoxycarbonyl)oxy)ethoxy)ethyl)carbamate (CAS CATO-C3D-263235)
- N-Nitroso Desloratadine Impurity A (CAS CATO-C4X-143056)
- 203510-68-3 1H-Indol-3-yl(4-phenylpiperazino)methanone MFCD03305786 (CAS 203510-68-3)
- Atropine EP Impurity E(7-Hydroxyhyoscyamine) (CAS 949092-65-3)
- Finerenone Impurity 4 (CAS 2640280-86-8)
- Tenoxicam EP Impurity E (CAS 94040-09-2)
- Ipratropium Impurity 24 (Mixture of Isomers) (CAS 17812-46-3)
- 3-(Trimethylsilyl)propane-1,2-diol (CAS 119235-89-1)
- 4-Methylfuran-2-carbohydrazide (CAS 1313406-05-1)
- Ethyl 1-(pyridin-3-ylmethyl)-1H-pyrazole-3-carboxylate (CAS 2250242-67-0)
- 2-(4-Ethoxy-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1218791-20-8)
- 2-(Chloromethoxy)-1-methyl-4-nitrobenzene (CAS 1533055-85-4)
- 2-(Methylamino)-2-oxoethyl 3,5-dimethylisoxazole-4-carboxylate (CAS 801256-79-1)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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