Entecavir EP Impurity B CAS 1367369-77-4
| CAS No. | 1367369-77-4 |
| Molecular Formula | C12H15N5O3 |
| Molecular Weight | 277.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Entecavir EP Impurity B is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Entecavir EP Impurity B (CAS 1367369-77-4) is a certified pharmaceutical impurity reference standard with the molecular formula C12H15N5O3 and a molecular weight of 277.28 g/mol.
The molecular framework of Entecavir EP Impurity B (C12H15N5O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Entecavir EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H15N5O3 |
| Molecular Weight | 277.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 5 |
Related Entecavir Standards
- Entecavir (CAS 142217-69-4)
- Entecavir EP Impurity D (CAS 1367369-80-9)
- Entecavir Impurity 17 (CAS CATO-C4X-107717)
- Entecavir Impurity 71 (CAS CATO-C4X-107771)
- Entecavir EP Impurity A (CAS 1367369-78-5)
- Entecavir-13C2,15N (CAS 1329796-53-3)
- Entecavir Impurity 76 (Racemic mixture) (CAS CATO-C4X-107776)
- Entecavir Impurity 59 (CAS CATO-C4X-107759)
Recommended Standards
- (1S,3S,4R)-Entecavir (CAS CATO-C4X-10775)
- (1R,3S,4S)-Entecavir (CAS 1367369-81-0)
- 1R 3S 4R-Ent-Entecavir (CAS 188399-46-4)
- (1R,3R,4R)-Entecavir (CAS 1367369-76-3)
- Epalrestat Impurity 13 (CAS 66051-14-7)
- Daclatasvir Impurity 16 (CAS CATO-C4X-184816)
- Baricitinib Impurity 59 (CAS CATO-C4X-226059)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com