Entecavir EP Impurity A CAS 1367369-78-5
| CAS No. | 1367369-78-5 |
| Molecular Formula | C12H15N5O3 |
| Molecular Weight | 277.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Entecavir EP Impurity A (CAS 1367369-78-5, C12H15N5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Entecavir EP Impurity A (C12H15N5O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Entecavir EP Impurity A under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H15N5O3 |
| Molecular Weight | 277.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 5 |
Related Entecavir Standards
- Entecavir (CAS 142217-69-4)
- Entecavir EP Impurity D (CAS 1367369-80-9)
- Entecavir Impurity 17 (CAS CATO-C4X-107717)
- Entecavir EP Impurity B (CAS 1367369-77-4)
- Entecavir Impurity 71 (CAS CATO-C4X-107771)
- Entecavir-13C2,15N (CAS 1329796-53-3)
- Entecavir Impurity 76 (Racemic mixture) (CAS CATO-C4X-107776)
- Entecavir Impurity 59 (CAS CATO-C4X-107759)
Recommended Standards
- (1R,3R,4R)-Entecavir (CAS 1367369-76-3)
- (1R,3S,4S)-Entecavir (CAS 1367369-81-0)
- Olaparib Impurity 44 (CAS CATO-C4X-113544)
- Irbesartan Impurity 5 (CAS 152708-24-2)
- Bevantolol impurity 2 (CAS 204584-12-3)
- Flurbiprofen impurity 102 (CAS CATO-C4X-1444102)
- Biotin Impurity 5 (CAS 57229-92-2)
- Niraparib Impurity 12 (CAS CATO-C4X-232912)
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- 2-Chloro-N-(5,5-dimethyl-7-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)nicotinamide (CAS 1024435-77-5)
- Clopidogrel Impurity 78 (CAS CATO-C4X-102978)
- Peptide 431 (CAS CATO-CPTD788431)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com