Rotigotine EP Impurity D HCl CAS 1369532-05-7
| CAS No. | 1369532-05-7 |
| Molecular Formula | C18H23NOS |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 337.91 g/mol gives Rotigotine EP Impurity D HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Rotigotine EP Impurity D HCl (CAS 1369532-05-7), a pharmacopoeial impurity reference standard (molecular formula C18H23NOSHCl, MW 337.91 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Rotigotine EP Impurity D HCl (C18H23NOSHCl) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 337.91 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rotigotine EP Impurity D HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H23NOS HCl |
| Molecular Weight | 337.91 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Rotigotine Standards
- Rotigotine Impurity 11 (CAS 101403-24-1)
- Rotigotine impurity 23 (CAS 101470-23-9)
- Rotigotine EP Impurity B Hydrochloride (CAS 101470-23-9（free base）)
- Rotigotine Racemate HCl (CAS 102120-99-0)
- Rotigotine Impurity 40 (CAS 102121-00-6)
- Rotigotine EP Impurity A (CAS 112835-48-0)
- Rotigotine EP Impurity A HCl (CAS 112835-48-0（free base）)
- Rotigotine EP Impurity H (CAS 1148154-91-9)
Recommended Standards
- Bromhexine impurity 54 (CAS CATO-C4X-106054)
- Tryptophan EP Impurity F HCl (CAS 145545-23-9（free base）)
- Empagliflozin Impurity 162 (CAS 1715629-30-3)
- (((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(di-o-tolylphosphane) (CAS 85849-33-8)
- 7-Methyl-2-((4-nitrophenoxy)methyl)imidazo[1,2-a]pyridine (CAS 183365-21-1)
- 1170905-29-9 1-[6-(3-Methoxyphenyl)pyrimidin-4-yl]piperidine-3-carboxylic acid MFCD14281606 (CAS 1170905-29-9)
- 4-Chloro-2-methyl-6-(methylsulfanyl)pyrimidine (CAS 867131-59-7)
- 2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)acrylamide (CAS 304896-35-3)
- Thiazole-4-carboxylic acid hydrobromide (CAS 3973-07-7)
- Semaglutide impurity 257 (CAS CATO-C4X-2226257)
Why CATO?
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