1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene CAS 1373864-66-4
| CAS No. | 1373864-66-4 |
| Molecular Formula | C8H5ClF4O |
| Molecular Weight | 228.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene (CAS 1373864-66-4), molecular formula C8H5ClF4O and molecular weight 228.57 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 228.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF4O |
| Molecular Weight | 228.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Chloromethyl Standards
- 4-(Chloromethyl)-2-fluoro-1-(trifluoromethoxy)benzene (CAS 1089333-51-6)
- 2-(Chloromethyl)-1-fluoro-4-(trifluoromethoxy)benzene (CAS 1517586-69-4)
- 2-(Chloromethyl)-4-fluoro-1-(trifluoromethoxy)benzene (CAS 1806313-03-0)
- 2-(Chloromethyl)-5-fluoro-7-hydroxyquinazolin-4(3H)-one (CAS 2360859-98-7)
- N-(3-(Chloromethyl)-5-nitrophenyl)acetamide (CAS 1018448-90-2)
- N-[2-(chloromethyl)-4-nitrophenyl]acetamide (CAS 1171021-29-6)
- 3-(chloromethyl)-1-(2,6-difluorophenyl)-1H-pyrazole (CAS 1423025-88-0)
- 3-(Chloromethyl)-1-(2,4-difluorophenyl)-1h-pyrazole (CAS 1480177-94-3)
Recommended Standards
- 1-(2-Chloro-6-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1249544-27-1)
- 2-[Chloro(difluoro)methoxy]-1,3-difluoro-4-methyl-benzene (CAS 1404194-29-1)
- 1-(4-Chloro-3-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1247205-10-2)
- 1-[Chloro(difluoro)methoxy]-2,3-difluoro-4-methyl-benzene (CAS 1404194-41-7)
- Methyl 3-(aminomethyl)hexanoate HCl (CAS 916305-66-3（free base）)
- 2′-Deoxyuridine-2-13C;1,3-15N2 (CAS 369656-76-8)
- 2-Bromo-3,4,5,6-tetrafluorobenzoic acid (CAS 16583-04-3)
- n-{2-[3-(aminomethyl)phenoxy]ethyl}-N-methyloxan-4-amine (CAS 1153383-86-8)
- 3-(2-Chloroethyl)-1-(propan-2-yl)urea (CAS 883805-52-5)
- N-(4-methoxyphenyl)-2-(5-(morpholinosulfonyl)-2-oxopyridin-1(2H)-yl)acetamide (CAS 1251593-96-0)
- Cariprazine Impurity 44 (CAS CATO-C4X-240844)
- 8-Hydroxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one (CAS 37526-68-4)
- 3-Methoxy-4-(3-(4-methoxyphenoxy)propoxy)aniline (CAS 107276-40-4)
- Tumor Targeted Pro-Apoptotic Peptide (CAS 1926163-30-5)
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