1-[Chloro(difluoro)methoxy]-2,3-difluoro-4-methyl-benzene CAS 1404194-41-7
| CAS No. | 1404194-41-7 |
| Molecular Formula | C8H5ClF4O |
| Molecular Weight | 228.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-[Chloro(difluoro)methoxy]-2,3-difluoro-4-methyl-benzene (CAS 1404194-41-7), molecular formula C8H5ClF4O and molecular weight 228.57 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 1-[Chloro(difluoro)methoxy]-2,3-difluoro-4-methyl-benzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 228.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures 1-[Chloro(difluoro)methoxy]-2,3-difluoro-4-methyl-benzene under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF4O |
| Molecular Weight | 228.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (2-Chloro-6-fluoro-4-(trifluoromethyl)phenyl)hydrazine (CAS 110499-66-6)
- 1-(4-Chloro-3-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1247205-10-2)
- 1-(2-Chloro-6-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1249544-27-1)
- 2-[Chloro(difluoro)methoxy]-1,3-difluoro-4-methyl-benzene (CAS 1404194-29-1)
- (4-Chloro-3-fluoro-5-(trifluoromethyl)phenyl)methanol (CAS 1431329-65-5)
- (3-Chloro-2-fluoro-4-(trifluoromethyl)phenyl)methanol (CAS 1431329-79-1)
- 3-Chloro-4-fluoro-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1447606-46-3)
- 2-Chloro-4-fluoro-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1447607-62-6)
Recommended Standards
- 1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene (CAS 1373864-66-4)
- 1-(4-Chloro-2-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1514167-13-5)
- 4-(Chloromethyl)-2-fluoro-1-(trifluoromethoxy)benzene (CAS 1089333-51-6)
- 2-(Chloromethyl)-1-fluoro-4-(trifluoromethoxy)benzene (CAS 1517586-69-4)
- N-(2-Cyano-3-methylbutan-2-yl)-2-((5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio)acetamide (CAS 847840-90-8)
- 3-Isopropyl-1H-indol-6-amine (CAS 873055-16-4)
- 2-(1,3-Dioxolan-2-yl)-1-methyl-1H-indole (CAS 773095-30-0)
- 2-(1-Bromo-2,2,2-trifluoroethyl)-1,4-dichlorobenzene (CAS 1342777-81-4)
- 2-(4-(((1-Methyl-1H-pyrazol-3-yl)methyl)amino)-1H-pyrazol-1-yl)ethan-1-ol hydrochloride (CAS 1856096-34-8)
- Methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate (2S,3S)-2,3-bis(benzoyloxy)succinate (CAS 943516-64-1)
- 3-Methyl-5-phenyl-1,3,4-oxadiazol-2(3H)-one (CAS 879-60-7)
- 4-(2,4-Difluorobenzoyl)-N,N-dimethyl-1H-pyrrole-2-carboxamide (CAS 338404-10-7)
- 4-(tert-Butyl)-2-ethynyl-1-(2-iodovinyl)benzene (CAS 648933-86-2)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com