Fluticasone Impurity 25 CAS 1374153-88-4
| CAS No. | 1374153-88-4 |
| Molecular Formula | C27H29ClF2O6S |
| Molecular Weight | 555.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Fluticasone Impurity 25 (CAS 1374153-88-4, C27H29ClF2O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Fluticasone Impurity 25 (C27H29ClF2O6S) contains a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 555.03 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Fluticasone Impurity 25 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H29ClF2O6S |
| Molecular Weight | 555.03 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Furoate EP Impurity G (CAS 785806-96-4)
- Fluticasone Furoate EP Impurity H (CAS CATO-C4X-165026)
- Fluticasone Furoate Impurity 4 (CAS CATO-C4X-32544)
- Fluticasone Impurity 103 (CAS CATO-C4X-1650103)
- Fluticasone Impurity 81 (CAS CATO-C4X-165081)
- Fluticasone Impurity N7 (CAS 80474-27-7)
- Fluticasone Impurity 55 (CAS CATO-C4X-165055)
- Fluticasone Impurity 75 (CAS CATO-C4X-165075)
Recommended Standards
- 1-[3-[1-([1,1-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 1380088-03-8)
- Butyl 4-(4-chloro-3-nitrophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 500212-68-0)
- 870532-86-8 Bis(dodecylsulfanylthiocarbonyl) disulfide DTXSID40470687 (CAS 870532-86-8)
- sec-Butyl 4-(4-chloro-3-nitrophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 1005086-95-2)
- Bisoprolol Impurity 35 (CAS 1346602-59-2)
- Famotidine EP Impurity E (CAS 129083-44-9)
- Atrasentan Impurity 73 (CAS 1058404-70-8)
- 4-Ethynyl-2-methoxy-1-methylbenzene (CAS 69187-63-9)
- 2-Methyl-6-nitro-4-oxoquinazoline (CAS 24688-36-6)
- 1-(4-((Dimethylamino)methyl)thiophen-2-yl)ethan-1-one (CAS 959237-37-7)
- 2,4,6-Trimethylquinoline Sulfuric Acid Hydrate (CAS 7154-29-2)
- 5-Acetyl-2,6-diphenylpyrimidin-4(1H)-one (CAS 20954-87-4)
- 4-{[(4-methyl-1,3-thiazol-2-yl)methyl]amino}pyridine-2-carboxylic acid (CAS 1272273-03-6)
- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com