Fluticasone Furoate EP Impurity G CAS 785806-96-4
| CAS No. | 785806-96-4 |
| Molecular Formula | C27H29ClF2O6S |
| Molecular Weight | 555.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Fluticasone Furoate EP Impurity G is closely related to a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Fluticasone Furoate EP Impurity G (CAS 785806-96-4, C27H29ClF2O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fluticasone Furoate EP Impurity G (C27H29ClF2O6S) contains a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H29ClF2O6S |
| Molecular Weight | 555.03 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Impurity 25 (CAS 1374153-88-4)
- Fluticasone Furoate EP Impurity H (CAS CATO-C4X-165026)
- Fluticasone Furoate Impurity 4 (CAS CATO-C4X-32544)
- Fluticasone Impurity 103 (CAS CATO-C4X-1650103)
- Fluticasone Impurity 81 (CAS CATO-C4X-165081)
- Fluticasone Impurity N7 (CAS 80474-27-7)
- Fluticasone Impurity 55 (CAS CATO-C4X-165055)
- Fluticasone Impurity 75 (CAS CATO-C4X-165075)
Recommended Standards
- 1-[3-[1-([1,1-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 1380088-03-8)
- Butyl 4-(4-chloro-3-nitrophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 500212-68-0)
- sec-Butyl 4-(4-chloro-3-nitrophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 1005086-95-2)
- N-((2-benzyl-3-phenylisoxazolidin-5-yl)methyl)-N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methylmethanesulfonohydrazide (CAS 339276-56-1)
- Trazodone Impurity 83 (CAS CATO-C4X-177283)
- Lovastatin Impurity N1 (CAS 106909-04-0)
- Levofloxacin Impurity 64 (CAS 1607796-83-7)
- 8-Fluoroquinoline-2-carboximidamide hydrochloride (CAS 1179359-70-6)
- 1-(Pyridin-3-ylmethyl)piperidin-4-ol dihydrochloride (CAS 1185318-61-9)
- tert-Butyl (4-acetyl-5-bromopyridin-2-yl)carbamate (CAS 1260664-96-7)
- (R)-2-amino-3-(2,5-dihydroxyphenyl)propanoic acid (CAS 60594-70-9)
- 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile (CAS 1220219-63-5)
- (E)-2-Phenylethenesulfonamide (CAS 64984-09-4)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
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