Fluticasone Furoate Impurity 4 CAS CATO-C4X-32544
| CAS No. | CATO-C4X-32544 |
| Molecular Formula | C27H29ClF2O6S |
| Molecular Weight | 555.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Fluticasone Furoate Impurity 4 (CAS CATO-C4X-32544) is a certified pharmaceutical impurity reference standard with the molecular formula C27H29ClF2O6S and a molecular weight of 555.03 g/mol.
Fluticasone Furoate Impurity 4 (C27H29ClF2O6S) contains a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H29ClF2O6S |
| Molecular Weight | 555.03 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Furoate EP Impurity G (CAS 785806-96-4)
- Fluticasone Impurity 25 (CAS 1374153-88-4)
- Fluticasone Furoate EP Impurity H (CAS CATO-C4X-165026)
- Fluticasone Impurity 103 (CAS CATO-C4X-1650103)
- Fluticasone Impurity 81 (CAS CATO-C4X-165081)
- Fluticasone Impurity N7 (CAS 80474-27-7)
- Fluticasone Impurity 55 (CAS CATO-C4X-165055)
- Fluticasone Impurity 75 (CAS CATO-C4X-165075)
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