Crizotinib S-Isomer CAS 1374356-45-2
| CAS No. | 1374356-45-2 |
| Molecular Formula | C21H22Cl2FN5O |
| Molecular Weight | 450.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Crizotinib S-Isomer (CAS 1374356-45-2), a certified reference material (molecular formula C21H22Cl2FN5O, MW 450.34 g/mol) for analytical method development and quality control.
Based on its molecular formula C21H22Cl2FN5O, Crizotinib S-Isomer contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 450.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C21H22Cl2FN5O |
| Molecular Weight | 450.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib (CAS 877399-52-5)
- Crizotinib impurity 20 (CAS CATO-C4X-102520)
- Crizotinib impurity 27 (CAS CATO-C4X-102527)
- Crizotinib-d5 (CAS 1395950-84-1)
- Crizotinib impurity 34 (CAS CATO-C4X-102534)
- Crizotinib impurity 35 (CAS CATO-C4X-102535)
- Crizotinib impurity 40 (CAS CATO-C4X-102540)
- Crizotinib Impurity 51 (CAS CATO-C4X-102551)
Recommended Standards
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