Crizotinib CAS 877399-52-5
| CAS No. | 877399-52-5 |
| Molecular Formula | C21H22Cl2FN5O |
| Molecular Weight | 450.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Crizotinib (CAS 877399-52-5), a certified reference material (molecular formula C21H22Cl2FN5O, MW 450.34 g/mol) for analytical method development and quality control.
Crizotinib (C21H22Cl2FN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H22Cl2FN5O |
| Molecular Weight | 450.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib impurity 20 (CAS CATO-C4X-102520)
- Crizotinib impurity 27 (CAS CATO-C4X-102527)
- Crizotinib S-Isomer (CAS 1374356-45-2)
- Crizotinib-d5 (CAS 1395950-84-1)
- Crizotinib impurity 34 (CAS CATO-C4X-102534)
- Crizotinib impurity 35 (CAS CATO-C4X-102535)
- Crizotinib impurity 40 (CAS CATO-C4X-102540)
- Crizotinib Impurity 51 (CAS CATO-C4X-102551)
Recommended Standards
- 3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine (CAS 877400-66-3)
- N'-[(1Z)-(4-Methoxyphenyl)methylidene]-2,5-bis(2,2,2-trifluoroethoxy)benzohydrazide (CAS 477864-03-2)
- N'-[(1Z)-(3-Methoxyphenyl)methylidene]-2,5-bis(2,2,2-trifluoroethoxy)benzohydrazide (CAS 477864-04-3)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com