Crizotinib-d5 CAS 1395950-84-1
| CAS No. | 1395950-84-1 |
| Molecular Formula | - |
| Molecular Weight | 455.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Crizotinib-d5.
CATO supplies Crizotinib-d5 (CAS 1395950-84-1), a certified reference material (molecular formula C21H17D5Cl2FN5O, MW 455.37 g/mol) for analytical method development and quality control.
The molecular framework of Crizotinib-d5 (C21H17D5Cl2FN5O) is characterized by deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Crizotinib-d5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H17D5Cl2FN5O |
| Molecular Weight | 455.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib impurity 34 (CAS CATO-C4X-102534)
- Crizotinib impurity 35 (CAS CATO-C4X-102535)
- Crizotinib impurity 40 (CAS CATO-C4X-102540)
- Crizotinib Impurity 51 (CAS CATO-C4X-102551)
- Crizotinib-d5 (CAS 1395950-48-7)
- Crizotinib (CAS 877399-52-5)
- Crizotinib impurity 20 (CAS CATO-C4X-102520)
- Crizotinib impurity 27 (CAS CATO-C4X-102527)
Recommended Standards
- 5-Fluoro-1-(4-fluorobenzyl)pyrimidine-2,4(1H,3H)-dione (CAS 86547-17-3)
- Aprepitant impurity 53 (CAS 502537-39-5)
- 2-Hydroxy-2-methyl-3-[3-(trifluoromethyl)benzenesulfonyl]-N-[4-(trifluoromethyl)phenyl]propanamide (CAS 338956-14-2)
- ((2R,3S,4R,5R)-5-(6-((4-Aminophenyl)thio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 89705-20-4)
- (6-Methyl-1H-imidazo[1,2-b]pyrazol-2-yl)methanamine (CAS 933715-55-0)
- tert-butyl 2-(difluoromethyl)piperazine-1-carboxylate (CAS 1270982-18-7)
- 6-Methoxyquinazoline-5,8-dione (CAS 87039-50-7)
- tert-Butyl 3-bromo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate (CAS 192189-17-6)
- 2-(4-Phenylphenyl)quinoline-4-carbohydrazide (CAS 351327-25-8)
- 3-((Chloromethyl)thio)-7-fluoro-1-methylquinolin-4(1H)-one (CAS 591781-26-9)
- 3-(4-Bromo-2-fluorophenyl)-2-hydroxypropanoic acid (CAS 1494909-95-3)
- 2-(2-(2-Iodophenyl)-2-oxoethyl)benzonitrile (CAS 898784-29-7)
- Methyl 5-propyl-1H-pyrrole-2-carboxylate (CAS 210841-59-1)
- Exenatide (CAS 141758-74-9（free base）)
Why CATO?
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