5-chloro-8-fluoro-1,6-naphthyridine CAS 1374652-06-8
| CAS No. | 1374652-06-8 |
| Molecular Formula | C8H14ClFN2 |
| Molecular Weight | 192.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-chloro-8-fluoro-1,6-naphthyridine (C8H14ClFN2) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
5-chloro-8-fluoro-1,6-naphthyridine (CAS 1374652-06-8) is a high-purity analytical reference standard with the molecular formula C8H14ClFN2 and a molecular weight of 192.66 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-chloro-8-fluoro-1,6-naphthyridine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H14ClFN2 |
| Molecular Weight | 192.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 8-Chloro-3-fluoro-[1,5]naphthyridine (CAS 1151802-02-6)
- 2-chloro-7-fluoroquinoxaline (CAS 1233932-59-6)
- 4-chloro-8-fluoroquinazoline (CAS 124429-27-2)
- 2-chloro-5-fluoro-quinazoline (CAS 1388028-12-3)
- 4-chloro-5-fluoroquinazoline (CAS 16499-60-8)
- 1-chloro-6-fluorophthalazine (CAS 23928-55-4)
- 2-chloro-6-fluoro-1,7-naphthyridine (CAS 2089054-23-7)
- 8-chloro-5-fluoro-1,7-naphthyridine (CAS 2306271-19-0)
Recommended Standards
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- 2-chloro-6-hydrazinyl-9H-purine (CAS 5404-88-6)
- {7-chloro-[1,2,4]triazolo[4,3-c]pyrimidin-3-yl}methanol (CAS 1183462-18-1)
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- (3S,4R)-1-(tert-butyl)-4-(4-chloro-2-fluorophenyl)pyrrolidine-3-carboxylic acid (CAS 757974-04-2)
- 15516-45-7 (2,4-Dimethylphenoxy)acetyl chloride DTXSID00608040 (CAS 15516-45-7)
- (2-(2-Hydroxypropan-2-yl)pyridin-4-yl)boronic acid (CAS 2225156-03-4)
- 6-(2-Aminoethyl)-4-nitropyridin-2-ol (CAS 1393552-93-6)
- 3-(4-Bromophenyl)-7-phenyl-2,6,7,8-tetrahydrocinnolin-5(4aH)-one (CAS 634155-12-7)
- 5-(4-Fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide (CAS 1072069-73-8)
- Insulin Degludec Impurity 12 (CAS CATO-C4X-215712)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com