Olmesartan Impurity 27 CAS 1378863-74-1
| CAS No. | 1378863-74-1 |
| Molecular Formula | C30H32N6O6 |
| Molecular Weight | 572.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Olmesartan Impurity 27 (CAS 1378863-74-1, C30H32N6O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Olmesartan Impurity 27 (C30H32N6O6) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H32N6O6 |
| Molecular Weight | 572.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 6 |
Related Olmesartan Standards
- Olmesartan Medoxomil Methyl Ether Impurity (CAS 896419-17-3)
- Olmesartan Impurity 77 (CAS 144689-78-1)
- Olmesartan impurity 6 (CAS CATO-C4X-10976)
- Olmesartan Impurity 54 (CAS CATO-C4X-109754)
- Olmesartan Medoxomil-D6 (CAS 1127298-67-2)
- Olmesartan Impurity 8 (CAS CATO-C4X-10978)
- Olmesartan (CAS 144689-63-4)
- Olmesartan Impurity 104 (CAS CATO-C4X-1097104)
Recommended Standards
- ZnAF-2 (CAS 321859-11-4)
- Ezetimibe Impurity N13 (CAS 1185883-40-2)
- ZnAF-1 (CAS 321859-09-0)
- Atorvastatin Lactone Diepoxide (CAS 1046118-40-4)
- Choline Fenofibrate Impurity 30 (CAS CATO-C4X-101830)
- Calcipotriol Impurity A (CAS 126860-84-2)
- Cefaclor Impurity C37 (CAS 53994-83-5)
- 2-(2,5-dimethylphenyl)-6-fluoro-2,3-dihydro-1,2-benzothiazol-3-one (CAS 727664-91-7)
- 1-(5-((4-Chlorophenyl)carbamoyl)-1,3,4-thiadiazole-2-carbonyl)piperidine-3-carboxylic acid (CAS 1142210-08-9)
- 1,1,2-Trichloro-3,3,3-trifluoropropane (CAS 431-51-6)
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- 2-(3,3-Difluoroazetidin-1-yl)-3-(trifluoromethyl)pyridine (CAS 1779123-40-8)
- 1-Bromo-5-chloro-2-fluoro-3-iodobenzene (CAS 2135861-24-2)
- Liraglutide (14-31)TFA Salt (CAS CATO-C4X-19927)
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