Ezetimibe Impurity N13 CAS 1185883-40-2
| CAS No. | 1185883-40-2 |
| Molecular Formula | C33H30F2N2O5 |
| Molecular Weight | 572.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ezetimibe Impurity N13 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ezetimibe Impurity N13 (CAS 1185883-40-2, C33H30F2N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Ezetimibe Impurity N13 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 572.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H30F2N2O5 |
| Molecular Weight | 572.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Ezetimibe Standards
- Ezetimibe Impurtiy N5 (CAS 1621715-63-6)
- Ezetimibe Impurity 105 (CAS 1296129-16-2)
- Ezetimibe Impurity 107 (CAS 2363086-22-8)
- Ezetimibe Impurity 78 (CAS CATO-C4X-109878)
- Ezetimibe Impurity 120 (CAS 1197343-09-1)
- Ezetimibe Impurity 40 (CAS 190448-57-8)
- Ezetimibe Hydroxy Glucuronide (CAS 536709-33-8)
- Ezetimibe Phenoxy Glucuronide-d4 (CAS 1426174-41-5)
Recommended Standards
- Olmesartan Impurity 77 (CAS 144689-78-1)
- Atorvastatin Lactone Diepoxide (CAS 1046118-40-4)
- Olmesartan Impurity 27 (CAS 1378863-74-1)
- (2S,4S)-4-(Diphenylphosphino)-2-[(diphenylphosphino)methyl]-N-phenyl-1-pyrrolidinecarboxamide (CAS 74571-27-0)
- Atrasentan Impurity 197 (CAS CATO-C4X-3347197)
- Lincomycin EP Impurity E (CAS 13380-36-4)
- Tedizolid Impurity 87 (CAS 2095840-86-9)
- 4-(3,4-Dichlorophenoxy)piperidine (CAS 245057-73-2)
- 1-(Phenoxymethyl)-1H-benzo[d][1,2,3]triazole (CAS 111198-02-8)
- 8-chloro-1,2-dihydroquinazolin-2-one (CAS 60610-15-3)
- Dicyclohexylmethyl carbamate (CAS 6946-78-7)
- 4-Hydrazino-N-(3-methylphenyl)-4-oxobutanamide (CAS 443864-47-9)
- Ethyl 6-chloro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-34-2)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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