Clarithromycin impurity 14 CAS 138109-92-9
| CAS No. | 138109-92-9 |
| Molecular Formula | C38H69NO13 |
| Molecular Weight | 747.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Clarithromycin impurity 14 (CAS 138109-92-9), a pharmacopoeial impurity reference standard (molecular formula C38H69NO13, MW 747.95 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Clarithromycin impurity 14 is typically off-white to pale yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 747.95 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C38H69NO13 |
| Molecular Weight | 747.95 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 1 |
Related Clarithromycin Standards
- Clarithromycin (CAS 81103-11-9)
- Clarithromycin EP Impurity J(Roxithromycin EP Impurity C) (CAS 111321-02-9)
- Clarithromycin EP Impurity M (CAS 127182-43-8)
- Clarithromycin-N-methyl-d3 (CAS 959119-22-3)
- Clarithromycin-D3 (CAS 959119-17-6 (unlabeled))
- Clarithromycin-N-methyl-d3 (CAS CATO-CCAD302748)
- Clarithromycin-13C-d3 (CAS 81103-11-9(unlabelled))
- Clarithromycin EP Impurity H (CAS 127140-69-6)
Recommended Standards
- Erythromycin Impurity 50 (CAS 37152-22-0)
- Eribulin Impurity 3 (CAS CATO-C4X-26503)
- 13-Desethyl-13-propyl-Erythromycin A (CAS 288584-78-1)
- Eribulin Impurity 2 (CAS 1534341-96-2)
- Ledipasvir Impurity 33 (CAS CATO-C4X-331333)
- Candesartan Cilexetil EP Impurity B (CAS 869631-11-8)
- Resmetirom impurity 130 (CAS CATO-C4X-2912130)
- 4-(4-Bromophenyl)-3H-1,2,4-triazole-3,5(4H)-dione (CAS 107553-79-7)
- Methyl (3S)-3-amino-3-(3-chlorophenyl)propanoate (CAS 309757-83-3)
- Ethyl 4-(3-methylphenyl)-2,4-dioxobutanoate (CAS 151646-26-3)
- Leflunomide EP Impurity G (CAS 724429-16-7)
- 2-(3,4,5-Trimethoxyphenyl)imidazole (CAS 1119531-23-5)
- 1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid (CAS 85375-85-5)
- Insulin Degludec impurity 4 (CAS CATO-C4X-21574)
Why CATO?
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