Resmetirom impurity 130 CAS CATO-C4X-2912130
| CAS No. | CATO-C4X-2912130 |
| Molecular Formula | C17H14Cl2N6O6 |
| Molecular Weight | 469.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 469.24 g/mol gives Resmetirom impurity 130 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Resmetirom impurity 130 (CAS CATO-C4X-2912130) is a certified pharmaceutical impurity reference standard with the molecular formula C17H14Cl2N6O6 and a molecular weight of 469.24 g/mol.
Resmetirom impurity 130 (C17H14Cl2N6O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Resmetirom impurity 130 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H14Cl2N6O6 |
| Molecular Weight | 469.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Resmetirom Standards
- Resmetirom impurity 91 (CAS CATO-C4X-291291)
- Resmetirom impurity 56 (CAS 3033842-98-4)
- Resmetirom impurity 112 (CAS CATO-C4X-2912112)
- Resmetirom Impurity 31 (CAS CATO-C4X-291231)
- Resmetirom impurity 139 (CAS 1581304-53-1)
- Resmetirom impurity 16 (CAS 920509-33-7)
- Resmetirom Impurity 34 (CAS CATO-C4X-291234)
- Resmetirom Impurity 42 (CAS CATO-C4X-291242)
Recommended Standards
- 2,2'-((2,2-Bis(chloromethyl)propane-1,3-diyl)bis(oxy))bis(5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide) (CAS 83044-97-7)
- 4,5-Dichloro-6-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1346447-26-4)
- 6,7-Dichloro-4-(4-fluorophenyl)-2-(4-(trifluoromethoxy)phenyl)phthalazin-1(2H)-one (CAS 161716-26-3)
- 2-((2-(4-Bromophenyl)-2-oxoethyl)thio)-3-phenyl-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 692287-52-8)
- Apixaban Impurity 111 (CAS 104-94-9)
- Dasatinib Impurity 8 (CAS CATO-C4X-16078)
- Elagolix Impurity 52 (CAS 2756307-49-8)
- 2-Iodo-6-methylaniline (CAS 832133-11-6)
- Mirogabalin Impurity 106 Benzenesulfonic Acid (CAS CATO-C4X-2924197)
- Ethyl 2-(3-((tert-Butoxycarbonyl)amino)bicyclo[1.1.1]pentan-1-yl)acetate (CAS 2096992-05-9)
- 1-Propyl-1h-1,2,3-triazole-4-carboxylic acid (CAS 1266840-44-1)
- 1-(2-Phenoxyethyl)azetidin-3-amine (CAS 1342845-79-7)
- 2-((4-Fluorobenzyl)thio)-5-(1-methyl-3-(trifluoromethyl)-1H-thieno[2,3-c]pyrazol-5-yl)-1,3,4-oxadiazole (CAS 478080-24-9)
- Semaglutide impurity 260 (CAS CATO-C4X-2226260)
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