Agomelatine Impurity 11 CAS 138113-07-2
| CAS No. | 138113-07-2 |
| Molecular Formula | C13H13NO2 |
| Molecular Weight | 215.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Agomelatine Impurity 11 (CAS 138113-07-2, C13H13NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Agomelatine Impurity 11 (C13H13NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H13NO2 |
| Molecular Weight | 215.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 1 |
Related Agomelatine Standards
- Agomelatine Impurity 25 (CAS 6836-22-2)
- Agomelatine Impurity 43 (CAS CATO-C4X-110843)
- Agomelatine Impurity 10 (CAS 20176-04-9)
- Agomelatine Impurity 34 (CAS 27533-69-3)
- Agomelatine Impurity 17 (CAS 92041-01-5)
- Agomelatine Impurity 44 (CAS 55917-07-2)
- Agomelatine Impurity 26 (CAS 945853-23-6)
- Agomelatine Impurity 27 (CAS CATO-C4X-110827)
Recommended Standards
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- Perindopril Impurity 90 (CAS CATO-C4X-125290)
- Pitavastatin Impurity 34 (CAS CATO-C4X-103734)
- Rivastigmine Impurity 28 (CAS CATO-C4X-138428)
- Etonogestrel Impurity 1 (CAS 947193-18-2)
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- 2-Bromo-1-(8-azaspiro[4.5]decan-8-yl)ethan-1-one (CAS 1411607-57-2)
- N-(1,3,4,7-Tetrachloro-9-oxo-9H-fluoren-2-yl)acetamide (CAS 92430-43-8)
- 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1196985-65-5)
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- Methyl 4-[3-(2-cyanoacetyl)-2,5-dimethyl-1H-pyrrol-1-yl]benzoate (CAS 729578-83-0)
- semaglutide (CAS 782487-28-9)
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