Agomelatine Impurity 34 CAS 27533-69-3
| CAS No. | 27533-69-3 |
| Molecular Formula | C13H14O3 |
| Molecular Weight | 218.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 218.25 g/mol gives Agomelatine Impurity 34 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Agomelatine Impurity 34 (CAS 27533-69-3, C13H14O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Agomelatine Impurity 34 (C13H14O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 218.25 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14O3 |
| Molecular Weight | 218.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
Related Agomelatine Standards
- Agomelatine Impurity 10 (CAS 20176-04-9)
- Agomelatine Impurity 43 (CAS CATO-C4X-110843)
- Agomelatine Impurity 17 (CAS 92041-01-5)
- Agomelatine Impurity 44 (CAS 55917-07-2)
- Agomelatine Impurity 26 (CAS 945853-23-6)
- Agomelatine Impurity 25 (CAS 6836-22-2)
- Agomelatine Impurity 11 (CAS 138113-07-2)
- Agomelatine Impurity 48 (CAS CATO-C4X-110848)
Recommended Standards
- Febuxostat Impurity 39 (CAS 161718-85-0)
- Tadalafil Impurity 88 (CAS 22032-65-1)
- Rosuvastatin Impurity 159 (CAS 140164-51-8)
- Tadalafil Impurity 49 (CAS 1379883-12-1)
- Suvorexant Impurity 49 (CAS CATO-C4X-181249)
- Acetylcysteine Impurity 40 xTFA salt (CAS 25779-79-7(Free Base))
- Adapalene Impurity 5 (CAS 106685-41-0)
- 6-Ethoxy-7-methoxy-1-methyl-3,4-dihydroisoquinoline (CAS 439146-82-4)
- Tert-butyl (R)-3-methyl-4-(6-nitropyridin-3-yl)piperazine-1-carboxylate (CAS 1433989-88-8)
- 2-[2-(Hydroxymethyl)phenyl]-2-propanol (CAS 55549-01-4)
- 2-((S)-1-(2-((S)-2-Amino-3-methylbutanamido)acetyl)pyrrolidine-2-carboxamido)acetic acid (CAS 243647-58-7)
- 2-{1-[(phenylsulfanyl)methyl]cyclopropyl}acetic acid (CAS 1489830-03-6)
- Tert-butyl 4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate (CAS 1187171-99-8)
- Semaglutide impurity 01 (CAS 1998701-31-7)
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